Breast cancer is one of the leading cause deaths among women. Although there are many advanced treatments, some types of breast cancer are refractory to therapy. Neoadjuvant systemic therapy has been regarded as an effective way that can be used throughout the cancer treatment process, which including topoisomerase inhibitors such as doxorubicin.
Cell-free DNA (cfDNA) is a high-performance screening test reporting fetal trisomies 13, 18, and 21. Although the sensitivity and specificity of cfDNA perform well compared to traditional tests, false-positive results are expected and may even be more likely than true positive results depending on a patient factors such as age.